The effect of Ascorbic Acid administration on inflammatory responses

Not Applicable

• Conditions: Exacerbation of inflammatory responses following brain-death occurrence.; Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified; R00-R99

• Registration Number: IRCT2012081710619N1
• Lead Sponsor: Vice chancellor for research, Shiraz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

10-60 y/o confirmed deadbrain case who has the UNOS standard criteria

Exclusion criteria: The deadbrain patient who had a cardiac arrest

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gene expression levels of IL6 and TNF-a genes. Timepoint: - 6 hours before the operation of deadbrain donor (in intervention group before starting to intervention) -Immediately after laparotomy -Immediately before clamping of Aorta. Method of measurement: Gene expression analysis using Real-Time PCR method.

Secondary Outcome Measures

Name	Time	Method
Serum levels of AST, ALT and Bilirubin -T. Timepoint: 1, 3 and 10 days afetr liver transplantation. Method of measurement: Serum levels of AST, ALT and Bilirubin-T.