The Effect of Ascorbic Acid on the blood loss in Total Knee Arthroplasty

Not Applicable

• Conditions: Total Knee Arthroplasty.; Osteoarthritis of knee, unspecified; M17.9

• Registration Number: IRCT20221104056393N1
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 25 July 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Candidates of total knee arthroplasty
patients who provide written informed consent to be included in this study

Exclusion Criteria

history of thromboembolic events like deep vein thrombosis or pulmonary embolism
history of cardiovascular disease like myocardial infarction or atrial fibrillation
being in pregnancy or in the lactation period
drug abusers or alcoholics
severe renal dysfunction
severe infection
the preoperative hemoglobin less than 10 g/dL
diagnosis of inflammatory arthritis like rheumatoid arthritis, pigmented villonodular synovitis and etc
clotting disorders including abnormal PT, PTT or INR

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total blood loss. Timepoint: Before intervention, 24h after intervention. Method of measurement: amount of Hemoglobin drop.

Secondary Outcome Measures

Name	Time	Method
Transfusion rate. Timepoint: Before the intervention, 24h after the intervention. Method of measurement: number of units of blood transfused.