Multicenter implementation of MR imaging studies in children with retinoblastoma for assessment of the value of craniofacial MRI screening of irradiated hereditary retinoblastoma survivors for early detection of second primary craniofacial tumors and to enhance survival

Completed

• Conditions: maligne tweede primaire tumoren bij erfelijke retinoblastoomoverlevers; new tumors in hereditary retinoblastoma; second primary tumors in hereditary retinoblastoma

• Registration Number: NL-OMON40748
• Lead Sponsor: Radiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Hereditary retinoblastoma patients of 8 through 18 years old that were irradiated for their eye tumors

Exclusion Criteria

claustrofobia
foreign non-MR compatible objects in the body

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To evaluate the ability of craniofacial MRI to detect SPTs early we will<br /><br>determine the sensitivity and specificity of MRI at detecting SPTs in<br /><br>irradiated hereditary retinoblastoma patients. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Five-year (overall and event-free) survival.<br /><br>2. Total number of MR scans performed to detect one SPT.</p><br>