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临床试验/CTRI/2025/08/093464
CTRI/2025/08/093464尚未招募不适用

Comparison of Mephentermine and Norepinephrine infusions for prevention of post-spinal hypotension during elective caesarean delivery:a randomised,double-blind trial.

Dr Ananya1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2025年11月21日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
100
试验地点
1
主要终点
Effect on umbilical artery pH

研究概览

简要总结

Spinal anesthesia is the preferred technique for elective caesarean section  due to rapid onset , ease of administration, and minimal foetal drug exposure. however,  one of the most frequent and clinically significant  complication is post spinal hypotension, resulting from sympathetic blockade leading to vasodilation and reduced venous return.in pregnant  patients it can lead to both maternal  and foetal complications  therefore  its crucial to ensure hemodynamic stability .this thesis emphasis on current strategies to overcome post spinal hypotension  with maximal efficacy.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Participant and Investigator Blinded

入排标准

年龄范围
18.00 Year(s) 至 49.00 Year(s)(—)
性别
Female

入选标准

  • Willing to participate, term uncomplicated singleton pregnancy, ASA1 and ASA2 Status, elective caesarean delivery.

排除标准

  • Refusal to participate, emergency c-section,multiple gestation, maternal or fetal disorders, absolute or relative contraindications to spinal anesthesia.

结局指标

主要结局

Effect on umbilical artery pH

时间窗: Post delivery of placenta( at baseline)

次要结局

  • Hemodyanamic parameters ( HR SBP DBP MAP SPO2)(APGAR score at 1 & 5 minutes)

研究者

发起方
Dr Ananya
申办方类型
Other [Self funded]
责任方
Principal Investigator
主要研究者

Dr Ananya

Indira Gandhi Institute of Medical Sciences, Patna

研究点 (1)

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