Targeting Inflammation for Endometrial Cancer Prevention
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- Mayo Clinic
- 入组人数
- 191
- 试验地点
- 2
- 主要终点
- Levels of eicosanoids and specialized pro-resolving mediators (SPMs) in visceral adipose tissue (VAT)
研究概览
简要总结
This study examines risk assessment and identifies prevention strategies for endometrial cancer. Collecting samples of blood and urine and risk assessments from patients with benign conditions or endometrial cancer may help doctors learn if there is a relationship between chronic inflammation and increase in risk for endometrial cancer.
详细描述
PRIMARY OBJECTIVE:
I. To develop a model for a biobank that can be expanded across the Mayo Enterprise and implemented at extramural collaborative sites, including underserved populations.
OUTLINE: This is an observational study.
Patients complete a risk factor questionnaire over 15 minutes. Patients also undergo collection of blood and urine during pre-operative visit and collection of tissue samples at the time of surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women over the age of 18 years old undergoing hysterectomy for any benign indication or endometrial cancer
排除标准
- •Women under the age of 18 years
- •Women with a history of cancer, except for endometrial cancer or non-melanoma skin cancer
- •Women with type 1 diabetes
- •Women that have received radiation or chemotherapy for cancer
结局指标
主要结局
Levels of eicosanoids and specialized pro-resolving mediators (SPMs) in visceral adipose tissue (VAT)
时间窗: Through study completion, up to 24 weeks
Will compare eicosanoid and SPM levels by case-control status (women with endometrial carcinoma and women with non-cancerous conditions) in all patients with linear models, adjusted for age and body mass index (BMI) (and menstrual date, if needed).
次要结局
- Ribonucleic acid (RNA) expression pathways related to inflammation in VAT(Through study completion, up to 24 weeks)