CTRI/2024/05/067424尚未招募不适用
A prospective interventional study to find out the effect of pre administration of 6 percent Hydroxyethyl starch for reduction of pain on propofol injection in patients undergoing general anaesthesia in Department of Anaesthesia SMS Medical College jaipur
Department of anaesthesiology SMS medical college jaipur1 个研究点 分布在 1 个国家目标入组 130 人开始时间: 2024年5月28日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- To compare the incidence of pain on propofol injection between the study groups
研究概览
简要总结
Propofol is most widely used intravenous agent for induction of anaesthesia. The immediate pain is due to irritation of vein and delayed pain is due to kin in release on propofol injection. Colloids have the capacity to modify endothelial cell junctions and permeability of the vascular endothelium by various substances and molecules.With this background we plan to conduct this study to compare the effect of pre-administration of 6% hydroxy ethyl starch for reduction of pain on propofol injection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients undergoing elective surgery under general anaesthesia.
- •Patients willing to give written informed consent.
- •ASA grade 1 and 2.
排除标准
- •Patients with history of allergy to propofol or hydroxy ethyl starch Patients with pre-existing renal or hepatic dysfunction.
- •Patients with cardiovascular disease,hypertension,diabetes.
- •Emergency surgeries.
结局指标
主要结局
To compare the incidence of pain on propofol injection between the study groups
时间窗: 0 second 10 second. 20 second. before loss of verbal contact
次要结局
- To compare the severity of pain on propofol injection between the study groups(0 second. 10 second. 20 second. before loss of verbal contact)
研究者
研究点 (1)
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