espiratory muscle activation by respiratory muscle training in patients with advanced COPD

Not Applicable

Conditions: J44.89

Registration Number: DRKS00005637

Lead Sponsor: niklinik Freiburg, Department für Innere Medizin, Klinik für Pneumologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting withdrawn before recruiting started

Sex: All

Target Recruitment: 15

Inclusion Criteria

Patients with advanced stable hypercapnic COPD and éstablished noninvasive mechanical ventilation

Exclusion Criteria

- severe hypoxia ((PaO2 < 60mmHg despite oxygen supplementation)
- haemodynamic instability within the last 24h
- neuromuscular disease
- acute infectin (procalcitonin >10 ng/ml and/or CRP > 10 mg/dl)
- missing cooperation
- use of sedative or analgetic agents within the last 6h
- body mass index > 30 kg/m2

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences in parasternal respiratory muscle activation (expressed as % of acitvation during maximal voluntary breathing maneuvers) applying electromyography during different modes respiratory muscle training (ITL vs TRB). Data recording and evaluation will be during the last breaths of each respiratory training session.

Secondary Outcome Measures

Name	Time	Method
- resting EMG of the respiratory muscles (M. sternocleidomastoideus, parasternal muscles, diaphragm) for the right / left body side<br>- maximal innervation as assessed by EMG during maximal voluntary breathing maneuvers (PImax, Sniff, TLC-breathing)<br>- effect of respiratory muscle training on dynamic hyperinflation, as assesse by spirometric measurement of the inspiratory capacity