Integrating Molecular Pathology, Radiology, and Genetics to Improve Breast Cancer Risk
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Mayo Clinic
- 入组人数
- 4,500
- 试验地点
- 2
- 主要终点
- Pathologic features
研究概览
简要总结
The purpose of this research is to better understand how benign breast diseases might lead to breast cancer, focusing on genetic factors and including a diverse range of participants to improve future diagnosis and treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Female patients, ages 18 to 100 years
- •Had a benign breast biopsy at Mayo Clinic between 2002-2022
排除标准
- •All male patients
- •Prior or concomitant diagnosis of BC
- •Diagnosis of BC within six months of benign breast disease
- •Denial of research authorization
- •Concurrent or post-biopsy bilateral prophylactic mastectomy
研究组 & 干预措施
Observational
Participants complete a questionnaire, undergo collection of saliva or blood samples, and have their medical records reviewed on study.
干预措施: Non-Interventional Study (Other)
结局指标
主要结局
Pathologic features
时间窗: Baseline (collection of blood or saliva sample)
Will examine pathologic features from benign tissue to define features related to breast cancer (BC) risk.
Radiologic features
时间窗: Baseline (collection of blood or saliva sample)
Will examine radiologic features from mammographic images at time of benign breast disease (BBD) to define features in mammogram images that predict BC risk among women who have a history of BBD. We will also assess whether these features predict BC risk among women without a history of BBD.
Molecular features
时间窗: Baseline (collection of blood or saliva sample)
Will examine molecular features to understand how molecular features, including DNA damage and repair work in the breast tissues of women with BBD and how this might relate to risk of developing BC
Pathologic features
时间窗: Baseline (collection of blood or saliva sample)
Will examine pathologic features from benign tissue to define features related to breast cancer (BC) risk.
Radiologic features
时间窗: Baseline (collection of blood or saliva sample)
Will examine radiologic features from mammographic images at time of benign breast disease (BBD) to define features in mammogram images that predict BC risk among women who have a history of BBD. We will also assess whether these features predict BC risk among women without a history of BBD.
Molecular features
时间窗: Baseline (collection of blood or saliva sample)
Will examine molecular features to understand how molecular features, including DNA damage and repair work in the breast tissues of women with BBD and how this might relate to risk of developing BC
次要结局
未报告次要终点