Atelectasis Evaluated With Lung Ultrasound After Inhalation or Intravenous Induction in Pediatric Anesthesia: a Prospective, Observational, Propensity Scored Matched Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 326
- 试验地点
- 1
- 主要终点
- Signs of atelectasis
研究概览
简要总结
Children have a highly compliant chest wall and atelectasis formation occurs often during pediatric anesthesia. Inhalation induction is commonly performed in pediatric anesthesia but it is still unclear if this can have an effect on the development of atelectasis. Aim of this study is to investigate the impact of inhalation versus intravenous induction on atelectasis formation during anesthesia induction in children. Atelectasis will be evaluated with lung ultrasound before induction and right after induction.
详细描述
Respiratory complications, among which atelectasis, are a common cause of adverse events in pediatric anesthesia. Lung ultrasound (LUS) examination is a point of care, non-invasive, radiation-free tool with high sensitivity and specificity for the identification of anesthesia-induced atelectasis in children.
Inhalation induction is commonly performed in pediatric anesthesia to avoid pain at venipuncture or to facilitate vein cannulation. This technique has been associated with a higher rate of respiratory adverse events but no study has investigated the role of inhalation or intravenous induction on lung atelectasis development in pediatric anesthesia.
The investigators will perform this study aiming to describe the impact of inhalation versus intravenous induction technique on atelectasis formation during anesthesia induction in children of different ages.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 0 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled for elective surgery under general anesthesia
- •parental consent
排除标准
- •American Society of Anesthesiologists (ASA) physical status III-VI
- •neuromuscular disease
- •chronic lung disease
- •cardiopathy
- •thoracic cage malformations
- •chronic home ventilation (either invasive or non-invasive)
- •positive history of foreign body inhalation
- •required immediate life-saving procedures
- •lack of parental consent
结局指标
主要结局
Signs of atelectasis
时间窗: Upon completion of induction and and subsequent controls at end of surgery and 1 postoperative day
Number of lung areas presenting a sub pleural consolidation
Global LUS score
时间窗: Upon completion of induction and subsequent controls at end of surgery and 1 postoperative day
Sum of the LUS scores given to all the lung areas. Score points vary from 0 to 3, where 0 means normality of the lung and 3 refers to complete loss of aeration-tissue-like pattern or consolidation.
次要结局
未报告次要终点
研究者
Anna Camporesi
Principal Investigator
Vittore Buzzi Children's Hospital