Molecular mechanisms in the host-pathogen interaction in neonates; an approach on the level of gene and protein expressio

Withdrawn

• Conditions: blood stream infection; 10004018

• Registration Number: NL-OMON30013
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

Admission on neonatal intensive care unit
Clinical signs of late-onset sepsis
Weight at least 750 g

Exclusion Criteria

Birth weight < 750 g
No informed consent
Positive blood culture for bacteria other than coagulase-negative staphylococci

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Difference in genomic transcription profiles and protein profiles between<br /><br>patients and controls.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To gain insight in similarities and differences in gene expression profiles<br /><br>between neonates suffering from CoNS sepsis and children suffering from<br /><br>meningococcal sepsis. </p><br>