Bacteria and host immune response as factors modulating visceral afferent processing in Irritable Bowel Syndrome: manipulation of visceral hypersensitivity with probiotic bacteria

• Conditions: Irritable Bowel Syndrome; MedDRA version: 9.1Level: LLTClassification code 10023003Term: Irritable bowel syndrome

• Registration Number: EUCTR2007-000008-34-GB
• Lead Sponsor: orth West London Hospitals NHS Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2007-05-30
• Last Update Posted: 26 June 2012

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

The inclusion criteria are:
Patients fulfilling the Rome II criteria for the diagnosis of IBS
Normal blood investigations (FBC, ESR, CRP, LFT, RCF, Ferritin, Vitamin B12)
Normal colonoscopy.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

The exclusion criteria will be:
A history of weight loss
Rectal bleeding
Fevers
Psychiatric illness (severe depression, anxiety, mania and schizophrenia)
Active infection
Recent antibiotic therapy or anti-inflammatory medication within previous 4 weeks

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified