The immune system and microbial tone in relation to NAFLD/NASH before and after BARIatric surgery in the morbidly obese in Amsterdam; the BARIA cohort study.
Recruiting
- Conditions
- obesitynafld-nashbariatric surgery
- Registration Number
- NL-OMON22589
- Lead Sponsor
- amc
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 1500
Inclusion Criteria
Scheduled for bariatric surgery
-Ability to provide informed consent
Exclusion Criteria
-Known genetic basis for insulin resistance or glucose intolerance
-All medical and psychiatric conditions except for obesity related diseases.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To identify microbial, immunological and metabolic markers associated with weightloss after bariatric surgery. To this end, we will collect before, during surgery and after 2 years follow up.<br><br>
- Secondary Outcome Measures
Name Time Method To apply systems biology approach to identify hierarchy of driving mechanisms (microbial, immunological and metabolic markers) in relation to diet and satiety involved in the long term beneficial weight loss effects of bariatric surgery that can be used for personalised medicine