Comparison of the diagnostic accuracy of thoracic ultrasonography and portable chest X-ray in the diagnosis of ventilator-associated pneumonia
- Conditions
- J15Ventilator-associated pneumoniaBacterial pneumonia, not elsewhere classified
- Registration Number
- DRKS00011119
- Lead Sponsor
- Abteilung für IntensivmedizinBonifatius Hospital Lingen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 100
• Mechanical ventilation
• Intensive care unit treatment expected to be required for at least 48 hours at the time of screening
• Presence of signs and symptoms suggestive for VAP (signs of worsening respiratory function (an increase of FiO2 by 0.15 or an increase of PEEP by > 2 mbar or a new onset of purulent sputum or a new onset of abnormal breath sounds) accompanied by signs and symptoms of systemic inflammation (temperature > 38°C or <36°C or a white cell count < 4.0 x 109/l or >12.0 x 109/l or a C-reactive protein (CRP) level > 87 mg/l or increased by 41 mg/l from the previous value)
• Established diagnosis of pneumonia
• Surgery or severe injury to the thorax as the reason to the ICU-stay
• Age < 18 years
• Presence of dressings or skin conditions restricting access to the dorso-basal aspects of the thorax
• Body mass index > 40 kg m-2
• Confirmed pregnancy (ß-HCG >10U/l)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome is the diagnostic accuracy of TUS (Thoracic ultrasound) and portable chest X-ray in the detection of inflammatory consolidation in patients who have a diagnosis of VAP (Ventilator-associated pneumonia) confirmed by microbiologic laboratory results.
- Secondary Outcome Measures
Name Time Method Incidence of unexpected findings(e.g. pleural effusion, pneumothorax), resource utilization and interobserver variability of each imaging modality