Intestinal Microbiota of Breast Cancer Patients Undergoing Chemotherapy
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Transcriptional changes in gut microbiota
研究概览
简要总结
To date, few studies have addressed the link between gut microbiota and breast cancer chemotherapy, and previous studies have only provided a link between the gut and breast cancer.
详细描述
To date, few studies have addressed the link between gut microbiota and breast cancer chemotherapy, and previous studies have only provided a link between the gut and breast cancer.At present, studies on the interaction mechanism between intestinal flora and breast cancer mainly focus on two aspects: first, intestinal flora affects the occurrence and progress of breast cancer by affecting estrogen metabolism;Second, intestinal flora can influence the occurrence and treatment of breast cancer by affecting the regulation of the immune system.However, the specific types (or groups) of bacteria that promote the occurrence, development and mechanism of breast cancer still need to be further studied.In addition, since most of the current clinical studies on microorganisms and breast cancer are small sample studies, the accuracy of their conclusions remains to be studied.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years(Adult, Older Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Aged 18 to 65 years
- •First use of chemotherapy after breast cancer
排除标准
- •Pregnancy
- •Lactation
- •Cigarette smoking
- •Alcohol addiction
- •Hypertension
- •Diabetes mellitus
- •Lipid dysregulation
- •BMI > 27
- •Recent (< 3 months prior) use of antibiotics, probiotics, prebiotics, symbiotics, hormonal medication, laxatives, proton pump inhibitors, insulin sensitizers or Chinese herbal medicine
- •History of disease with an autoimmune component, such as MS, rheumatoid arthritis, IBS, or IBD
- •History of malignancy or any gastrointestinal tract surgery
研究组 & 干预措施
Disease group
First chemotherapy for breast cancer
干预措施: cyclophosphamide (Drug)
结局指标
主要结局
Transcriptional changes in gut microbiota
时间窗: baseline,1 day,7 day,14 days,22 days,29 days,36 days,44days,51days,58days,66days,73days,80days
The microbiota measured by 16S rRNA gene
次要结局
未报告次要终点
