Cognitive decline in cancer: Investigating a brain training interventio

Not Applicable

Recruiting

• Conditions: cancer; cancer-related cognitive impairment (CRCI); cancer psychosocial distress; neurodegenerative disorders; Neurological - Neurodegenerative diseases; Cancer - Any cancer; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation

• Registration Number: ACTRN12622001548729
• Lead Sponsor: Curtin University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-12-14
• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

From baseline, study inclusion criteria require participants to be aged over 18 years old, currently live in Perth and Peel regions of Western Australia (or close enough), have been diagnosed with non-CNS cancer, be currently undergoing any treatment, and have a working proficiency of the English language.

Participants invited to take part in the RCT will have cancer, access to and ability to use a phone/tablet/computer with internet for six weeks, and will demonstrate cognitive impairment, operationalised by scores meeting one or more of the following criteria (Vardy et al., 2007; Wefel et al., 2011): scores = 1.0SD below the norm on two or more objective cognitive measures; or score of = 1.5SD below the norm on one or more objective cognitive measures; Global Deficit Score (GDS) = 0.5 points. GDS = mean of deficit scores (which are converted from T scores). A GDS of 0.5 or greater indicates the mean of the objective cognitive measure scores is = 1SD below the norm. Note that norm” means demographic matched normative scores from neuropsychological compendium.

If necessitated, subjective impairment will also be considered; evidence thereof will be identified through FACT-Cog Perceived Cognitive Impairment (18-item) subscale scores < 54 (Dyk et al., 2020).

Exclusion Criteria

From baseline, exclusion criteria preclude participation of individuals with premorbid developmental / cognitive dysfunction; premorbid neurodegenerative conditions; pregnancy; and central nervous system metastases.

Inverse of the baseline inclusion criteria, participants not demonstrating cognitive impairment are not invited to the RCT.

Study & Design

• Study Type: Interventional
• Study Design: Not specified