Comparative Study of the Effectiveness of Two Different Doses of Intravenous Labetalol on Cardiovascular Response to Tracheal Extubatio
Phase 2
- Conditions
- Tracheal Extubation.
- Registration Number
- IRCT20180416039326N16
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
Normotensive patients who are candidates for elective surgery less than two hours under general anesthesia requiring endotracheal intubation
Age between 20 to 60 years
ASA one and two
Informed consent to participate in the study
Weight 55 to 85 kilogram
Exclusion Criteria
Pregnant women
Diabetic patients
Patients with uncontrolled underlying cardiovascular disease
Baseline heart rate less than 60 beats per minute and systolic blood pressure less than 90 mmHg
Patients with cerebrovascular diseases
Contraindication of the use of study medicines
Known allergy to anesthetics in the study
Opioid abuse
Taking medicines with cardiovascular effects
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Systolic blood pressure. Timepoint: Before extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Barometer.;Diastolic blood pressure. Timepoint: Before extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Barometer.;Pulse rate. Timepoint: Before extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Pulse oximetry.;Oxygen saturation percentage. Timepoint: Before extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Pulse oximetry.;Mean arterial pressure. Timepoint: Before extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Barometer.
- Secondary Outcome Measures
Name Time Method Duration of staying in recovery. Timepoint: Based on minutes from arrival to reaching the modified aldrete score of 9. Method of measurement: Information collection form.;Adverse airway response. Timepoint: During the time of staying in recovery. Method of measurement: Information collection form.;Hemodynamic complications. Timepoint: During the time of staying in recovery. Method of measurement: Information collection form.;Duration of extubation. Timepoint: Based on minutes from the time of discontinuing anesthetics to the time of extubation. Method of measurement: Information collection form.