Obstructive Sleep Apnoea and Adipose Tissue Dysfunction
- Conditions
- Obstructive Sleep ApnoeaObesityHypoxia
- Registration Number
- NCT02518633
- Lead Sponsor
- Royal Devon and Exeter NHS Foundation Trust
- Brief Summary
Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea. Reduced adipose tissue oxygen availability has been described in obesity and may also be a mechanism in obstructive sleep apnoea. Hypoxia induces inflammation and fibrosis in adipose tissue which are factors contributing to cardiovascular risk. The investigators hypothesize that adipose tissue's oxygen uptake is reduced in subjects with obstructive sleep apnoea by comparing in vivo AT oxygenation and blood flow in tissue of control subjects.
- Detailed Description
Assessment includes a adipose tissue biopsy and measurement of oxygenation and blood flow by a Clarke type electrodes and non-invasive Doppler techniques.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 15
- men with or without obstructive sleep apnoea
- weight loss interventions
- steroid use
- active smoking
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method pO2 in adipose tissue by Clarke type electrode 4 months Measurement of pO2 by Clarke type electrode
- Secondary Outcome Measures
Name Time Method blood flow in adipose tissue by laser Doppler techniques 4 months assessment of tissue blood flow by laser Doppler techniques
Trial Locations
- Locations (2)
NIHR Clinical Research Facility
🇬🇧Exeter, United Kingdom
Royal Devon and Exeter NHS Foundation Trust
🇬🇧Exeter, United Kingdom
NIHR Clinical Research Facility🇬🇧Exeter, United Kingdom