Assessment of Hypoxia in Adipose Tissue of Subjects With Obstructive Sleep Apnoea
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- pO2 in adipose tissue by Clarke type electrode
研究概览
简要总结
Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea. Reduced adipose tissue oxygen availability has been described in obesity and may also be a mechanism in obstructive sleep apnoea. Hypoxia induces inflammation and fibrosis in adipose tissue which are factors contributing to cardiovascular risk. The investigators hypothesize that adipose tissue's oxygen uptake is reduced in subjects with obstructive sleep apnoea by comparing in vivo AT oxygenation and blood flow in tissue of control subjects.
详细描述
Assessment includes a adipose tissue biopsy and measurement of oxygenation and blood flow by a Clarke type electrodes and non-invasive Doppler techniques.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •men with or without obstructive sleep apnoea
排除标准
- •weight loss interventions
- •steroid use
- •active smoking
结局指标
主要结局
pO2 in adipose tissue by Clarke type electrode
时间窗: 4 months
Measurement of pO2 by Clarke type electrode
次要结局
- blood flow in adipose tissue by laser Doppler techniques(4 months)
研究者
Katarina Kos
Consultant Physician
Royal Devon and Exeter NHS Foundation Trust