Effects and side effects of strong-acting opioids for the treatment of cancer-related pain: a study of the role of differences in metabolism (degradation) of the medicine and differences in genes
Recruiting
- Conditions
- Cancer-related painStrong-acting opioidsPharmacogenetic(s)PharmacokineticsOpioid rotationPain controlSide effectsKanker gerelateerde pijnsterk werkende opioidenFarmacogeneticaFarmacokinetiekOpioid rotatiePijncontroleBijwerkingen
- Registration Number
- NL-OMON29058
- Lead Sponsor
- Erasmus MC Cancer Institute, Rotterdam, the Netherlands
- Brief Summary
ot yet
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 350
Inclusion Criteria
Hospitalized patients treated with strong-acting opioids for moderate to severe cancer related nociceptive pain.
Starting treatment with strong-acting opioids or needing adjustment of current treatment
Exclusion Criteria
Estimated duration of hospitalisation < 72 hours
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Are variations in pharmacogenetics and/or pharmacokinetics related to insufficient pain control and/or the occurrence of intolerable side effects?<br>- To study the role of demographic and clinical factors on outcome of treatment<br>- To study how the factors mentioned above affect the outcome of opioid rotation<br>
- Secondary Outcome Measures
Name Time Method