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Clinical Trials/NCT05729958
NCT05729958
Not yet recruiting
Not Applicable

Total Ankle Replacement Using Guides, Expert Versus Trainee

Centre for Orthopaedic Research Alkmaar0 sites20 target enrollmentStarted: April 2024Last updated:

Overview

Phase
Not Applicable
Status
Not yet recruiting
Sponsor
Centre for Orthopaedic Research Alkmaar
Enrollment
20
Primary Endpoint
Postoperative TAR component accuracy

Overview

Brief Summary

Patient Specific Instrumentation (PSI) is thought to quicken joint arthroplasty surgery by shortening the operation time and improving alignment. Studies about the learning curve of PSI for total ankle replacement (TAR) are lacking because it was only introduced in 2014.

The investigators believe that PSI could give a beginning ankle surgeon, or surgeons new to TAR, an advantage since PSI facilitates the complex TAR procedure. As such, the availability of TAR in Dutch patients with end-stage ankle osteoarthritis could be extended. To estimate this potential of PSI for TAR, the investigators aim (1) to compare the alignment accuracy of TAR performed using PSI between a beginning and an experienced orthopedic surgeon, and (2) to determine the learning curve of TAR performed using PSI for a beginning foot and ankle specialist by comparing the operative time, complications, and patient-reported outcomes with those of an experienced specialist.

Detailed Description

Total ankle replacement (TAR) as treatment of end-stage osteoarthritis of the ankle is gaining popularity past few years, resulting in a growing number of TAR placed each year. This is an important progression because osteoarthritis of the ankle is suggested to be as disabling as chronic kidney injury or heart failure. Though TAR is proposed to be superior to ankle arthrodesis (AA) with regard to patient quality of life, it is not commonly available in the Netherlands. Merely 149 TARs were registered nationally in 2020.

Patient Specific Instrumentation (PSI) is thought to quicken the process by shortening the operation time and improving alignment. Though the literature is submerged in studies about the learning curves of PSI and TAR, research about the learning curve of PSI TAR is lacking because it was only introduced in 2014. Preliminary results showed that the use of PSI resulted in lower average pain scores and earlier recovery compared to TAR using standard instrumentation. Yet the absolute advantage of PSI was not established because of limited research. Furthermore, all previous studies were performed by skilled surgeons to eliminate the bias of inexperience.

The investigators believe that PSI could give a beginning ankle surgeon, or surgeon new to TAR, an advantage since PSI facilitates the complex TAR procedure. As such, the availability of TAR in Dutch patients with end-stage ankle osteoarthritis could be extended. To estimate this potential of PSI for TAR, the investigators aim (1) to compare the alignment accuracy of TAR performed using PSI between a beginning and an experienced orthopedic surgeon, and (2) to determine the learning curve of TAR performed using PSI for a beginning foot and ankle specialist by comparing the operative time, complications, and patient-reported outcomes with those of an experienced specialist. It is hypothesized that the alignment of PSI TAR performed by a beginning orthopedic surgeon does not significantly differ from one performed by an experienced surgeon. Furthermore, it is hypothesized that the operative time, complications, and patient-reported outcomes do not significantly differ between a beginning and an experienced orthopedic surgeon.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Other

Eligibility Criteria

Ages
18 Years to 90 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Patient can understand the study's meaning and is willing to sign the study-specific Informed Patient Consent Form.
  • Patient received the implantation of Infinity or Inbone prosthesis using PROPHECY PSI for primary TAR in
  • There are at least 3 months of follow-up data for this patient.
  • Patient can lay still during the length of duration of the CT-scan.

Exclusion Criteria

  • If per-operative the use of the PSI guides was abandoned.
  • Patients that underwent revision surgery (defined as original tibia of talar component change or removal).
  • Patients that endured other diseases that significantly impacted the post-operative period following TAR (e.g. amputation, severe extremity dysfunction due to a neurological or vascular impairment or trauma).

Outcomes

Primary Outcomes

Postoperative TAR component accuracy

Time Frame: 2-year follow-up assessment

Difference between the planned and obtained (anterior and sagittal) tibia angles.

Secondary Outcomes

  • Foot Function Index (FFI)(2-year follow-up assessment)
  • American Orthopedic Foot and Ankle Score (AOFAS)(2-year follow-up assessment)
  • Foot and Ankle Outcome Score (FAOS)(2-year follow-up assessment)

Investigators

Sponsor
Centre for Orthopaedic Research Alkmaar
Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Joyce L Benner, PhD

Principal Investigator

Centre for Orthopaedic Research Alkmaar

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