Two Different Doses of Tranexamic Acid for reduction of Perioperative Blood Loss in Cesarean Section: a randomized controlled study
- Conditions
- Pregnancy and Childbirth
- Registration Number
- PACTR202208859856197
- Lead Sponsor
- faculty of medicine suez canal university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Female
- Target Recruitment
- 134
1)Age from 18- 45 years.
2)Patients are ASA I (American Society of Anesthesiology physical status Grade I) = (normal healthy patients) or ASA II (American Society of Anesthesiologists physical status Grade II) = (patients with mild systemic disease and no functional limitations).
3)term with singleton uncomplicated pregnancies.
4)Body mass index of at most 40 kg/m2.
1)Parturient with peri-partum disorders as DM, HTN, cardiac diseases, Sickle cell disease or bleeding disorders History of venous (deep vein thrombosis and/or pulmonary embolism) or arterial (angina pectoris, myocardial infarction, stroke) thrombosis.
2)Known case of coagulation disorders.
3)Severe anemia.
4)Allergy to TXA.
5)Severe medical and surgical complications involving the heart, liver, kidney, brain, and blood disorder.
6)Abnormal placenta such as placenta previa and placental abruption.
7)Pregnancy related complication like severe preeclampsia,
8)Pregnancy with <37 weeks gestational age.
9)Woman on anticoagulant therapy during the week
10)Refusal to participate in the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Amount pf perioperative blood loss as mentioned before<br>2.Change in hemoglobin level in gm measured after 48 hrs<br>
- Secondary Outcome Measures
Name Time Method 3.Need for vasopressors to maintain blood pressure within accepted level<br>4.Incidence of severe PPH, defined by blood loss =1000 mL.<br>5.Incidence of nausea, vomiting and thrombosis<br>