To Compare the peripheral perfusion index and serum lactate levels as a marker of tissue perfusion in patients undergoing elective open heart surgery with cardiopulmonary bypass

Completed

• Conditions: Combined rheumatic disorders of mitral, aortic and tricuspid valves,

• Registration Number: CTRI/2024/01/061997
• Lead Sponsor: Dr Prakash Chandra

Brief Summary

The primary purpose of the protocol is to correlate the peripheral erfusion index with serum lactate levels in cardiac surgeries involving use of cardiopulmonary bypass. We have hypothesised that there will be early change in perfusion index prior to the change in serum lactate levels.By knowing the correlation we can take steps to avoid to increase hypoperfusion time and rule out the cause and manage accordingly.

Detailed Description

Not available

Study Timeline

• Study Completion: 2024-05-31
• Study Start: 2024-09-02
• Last Update Posted: 2024-12-11

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

All patients with American Society of Anaesthesiologists Physical Status 3 or 4 of age 20 to 60 years planned for elective open heart surgery under cardiopulmonary bypass.

Exclusion Criteria

Patients with history of severe hepatic renal dysfunction and Chronic obstructive pulmonary disease with FEV1 less than 50 percent Patients with cyanotic heart disease Patients with left ventricular ejection fraction less than 40 percent Patients undergoing combined surgical procedures CABG combined with valve surgery or aortic procedures and carotid surgery Redo-procedures within one year of previous surgery Patients with serum lactate more than 3 mmol per litre preoperatively Patients with BMI of more than 32 kg per meter square Pregnant patients Patients with sepsis and shock states Patients with nail pathologies Patients in whom modified Allens test could not be performed or is negative.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare and correlate the peripheral perfusion index with serum lactate levels	T1 preCPB | T2 cooling | T3 hypothermia | T4 rewarming | T5 post- CPB | T6 6 hours postoperatively | T7 12 hours postoperatively | T8 24 hours postoperatively

Secondary Outcome Measures

Name	Time	Method
To correlate changes in peripheral perfusion index & serum lactate values with changes in haemodynamic indices	T1 pre CPB

Trial Locations

Locations (1)

Pt BD sharma PGIMS Rohtak; 🇮🇳 Rohtak, HARYANA, India

Pt BD sharma PGIMS Rohtak

🇮🇳Rohtak, HARYANA, India

Dr Prakash Chandra

Principal investigator

9674175008

pcsgpgi123@gmail.com