Influence of RYANodyne receptor 1 mutations On Pulmonary arterial Pressure And ventilation During isocapnic hypoxia.

Recruiting

• Conditions: Malignant hyperthermiahypoxiahypoxic ventilatory responsehypoxic pulmonary vasoconstriction

• Registration Number: NL-OMON25834
• Lead Sponsor: MC

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

Healthy Malignant Hyperthermia patients with a phenotypic high susceptibility and a proven causative mutation.
The major inclusion criteria are that the subject has echo evidence of tricuspid regurgitation during systole, which is not clinically relevant but in fact can be demonstrated in most normal individuals.

Exclusion Criteria

1. Obesity (BMI > 30);

2. Presence of medical disease: heart-, lung-, liver-, kidney- and lung disease; diabetes;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Systolic PAP;<br /><br>2. HVR.

Secondary Outcome Measures

Name	Time	Method
1. Systolic and diastolic cardiac functions;<br /><br>2. Vital and ventilatory parameters.