Influence of ryanodyne receptor 1 mutations on pulmonary arterial pressure and ventilation during isocapnic hypoxia

Withdrawn

• Conditions: pulmonary hypertension; 10057166

• Registration Number: NL-OMON36376
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

Healthy Malignant Hyperthermia patients with a phenotypic high susceptibility and a proven causative mutation.
The major inclusion criteria are that the subject has echo evidence of tricuspid regurgitation during systole, which is not clinically relevant but in fact can be demonstrated in most normal individuals.

Exclusion Criteria

• Obesity (BMI > 30)
• Presence of medical disease: heart-, lung-, liver-, kidney- and lung disease; diabetes
• Presence of psychiatric disease
• History of chronic alcohol or drug use
• Possibility of pregnancy
• Lactation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>HPV</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>cardiac parameters<br /><br>hypoxic ventilatory response</p><br>