Effect of Medroxy progesteron in Chronic Obstructive Pulmonary Disease (COPD) exacerbatio

Phase 3

Recruiting

• Conditions: Chronic Obstructive Pulmonary Disease(COPD) Exacerbation.; Chronic obstructive pulmonary disease with acute exacerbation, unspecified; J44.1

• Registration Number: IRCT20211031052922N1
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 January 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Chronic Obstructive Pulmonary Disease (COPD) exacerbation patients who has one of this criteria(dyspnea, increased sputum volume, and a change in the nature of sputum)
COPD exacerbation patient who needs Non Invasive Ventilation (NIV)
Age between 30-80
Signing the written informed consent

Exclusion Criteria

Requiring mechanical ventilation by the time of admission
Having a current or history of thromboembolic diseases like Pulmonary Thrombosis Embolie (PTE), active thrombophelebitis, Deep Vein Thrombosis (DVT)
History of cerebrovascular disease, history of myocardial infarction (MI) and stroke
Unexplained vaginal bleeding
Hepatic diseases
Pregnancy
History of breast cancer or any estrogen or progesterone dependent tumors
History of allergy to hormonal drugs containing progesterone
Stable and frequent vomiting
Decreased level of consciousness
Deformity or trauma in face

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ICU admission. Timepoint: Daye1;3;5. Method of measurement: doctors reports.;Intubation. Timepoint: Days1,3,5. Method of measurement: Doctors reports.;Venous blood gase. Timepoint: Days1,3,5. Method of measurement: ABG analysor.;O2saturation. Timepoint: Days1,3,5. Method of measurement: Pulse oximetery.

Secondary Outcome Measures

Name	Time	Method
Hospitalization days. Timepoint: In day 5 and days of discharge. Method of measurement: Days of hospitalization.;Dyspnea score. Timepoint: Days 1,3,5. Method of measurement: Borg scale.;Non Invasive Ventilation(NIV) hours/day usage. Timepoint: Days 1,3,5. Method of measurement: Based on doctors reports.