Evaluation of effects of oral medroxyprogesterone and donepezil in improvement of respiratory status and facilitation in weaning of mechanical ventilation in patients undergoing mechanical ventilation in ICUs
- Conditions
- weaning of mechanical ventilation.
- Registration Number
- IRCT20190810044500N2
- Lead Sponsor
- Yazd University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 45
Mechanical ventilation through endotracheal tube for at least 24 hours
oxygen saturation greater than 90%
FIO2 less than 50%
PEEP less than 8 cm water
hemodynamic stability over the past 12 hours
sedation withdrawal or sedation reduction Over the past 48 hours
neurological status stabilized with Ramsay's score less than 5
temperature between 36 and 39 degrees
Pregnancy or lactation
under 18 years of age
tracheostomy
hepatic encephalopathy
cerebral edema
acute hydrocephalus
myasthenia gravis
Acute polyneuropathy
lack of decision to discontinue respiratory support
prolonged cardiac arrest with poor neurologic prognosis
coincident extubation with day one
acute right ventricular failure
renal failure
plasma urea exceeding (25 mol / L), Plasma creatinine greater than (180 mol / min) or creatinine clearance less than 30 ml / min, or more than 25% increase in creatinine over the past 24 hours
contrast injection over the past six hours
Serum sodium level greater than (150 m Eq) / L
serum potassium level less than 3.5 (m Eq) / L
metabolic alkalosis with arterial pH greater than 7.5
need for sedation or unconsciousness
concurrent administration of drugs Potential respiratory stimulants such as doxapram and medroxyprogesterone
hypothyroidism
Known allergy to donepezil or medroxy progesterone
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood gas includes PO2, PCO2, PHCO3, O2 saturation and PH. Timepoint: Before intervention and one day after and after weaning of mechanical ventilation. Method of measurement: blood sample.;Hemoglobin. Timepoint: Before intervention and one day after and after weaning of mechanical ventilation. Method of measurement: blood sample.;Level of consciousness. Timepoint: Before intervention and one day after and after weaning of mechanical ventilation. Method of measurement: glass coma scale.;Sofa score. Timepoint: Before intervention and one day after and after weaning of mechanical ventilation. Method of measurement: Scoring based on pulmonary, coagulation, hepatic, cardiovascular, central nervous system and renal status.
- Secondary Outcome Measures
Name Time Method Duration of weaning. Timepoint: From the process of separation from the device to the patient's spontaneous breathing. Method of measurement: Counting the number of days.