Effect of injected medroxyprogesterone acetate on myometrial invasion in preoperative endometrial cancer: A randomized control trial

Not Applicable

• Conditions: - Preoperative surgery- endometrial cancer patient; Endometrial cancer; preoperative surgery; medroxyprogesterone acetate; myometrial invasion

• Registration Number: TCTR20190728003
• Lead Sponsor: Khon Kaen university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-07-28
• Study Completion: 2020-08-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: Female
• Target Recruitment: 120

Inclusion Criteria

- Endometrial cancer patient
- Waiting for surgery more than 4 weeks

Exclusion Criteria

1.History of medroxyprogesterone acetate allergy
2.Evidence of extrauterine cancer
3.history of breast cancer
4.hepatic disease
5.defined as persistent systolic blood pressure > 170 mmHg or diastolic blood pressure > 110 mmHg
6.osteoporosia, anorexia nervosa, rheumatoid arthritis, chronic glucocorticoid use
7. Using other progesterone drugs such as contraceptive drugs, injected or IUDs within 6 weeks before diagnosed of endometrial cancer
8. Venous thromboembolism;VTE
9. breast mass by physical examination or abnormal mammogram

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Myometrial invasion after surgery From the pathological report

Secondary Outcome Measures

Name	Time	Method
Cervical stromal invasion after surgery From the pathological report