Role of MRI in the Evaluation of Hepatic Metastases of Colorectal Cancer

Recruiting

• Conditions: Colorectal Cancer

• Registration Number: NCT05950503
• Lead Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Brief Summary

This study wants to evaluate the use of MRI in the managemente of mCRC with liver only metastases.

Detailed Description

This study wants to evaluate the use of MRI in the managemente of mCRC with liver only metastases.

Study Timeline

• Study Start: 2023-07-10
• Study First Submitted: 2023-07-10
• Study First Submitted QC: 2023-07-10
• Study First Posted: 2023-07-18
• Status Verified: 2025-08
• Last Update Submitted: 2025-08-25
• Last Update Posted: 2025-09-02
• Primary Completion: 2026-06-07
• Study Completion: 2027-06-07

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Age > 18 years;
• Histological diagnosis of colorectal cancer;
• Presence of liver metastases in the staging exams (chest-abdomen CT with contrast medium or PET-CT with 18-FDG);
• At least one measurable liver lesion according to RECIST 1.1 criteria;
• Adequate organ and marrow function.

Exclusion Criteria

• Age < 18 years;
• Inability to undergo MRI;
• Major contraindications to liver surgery;
• No written informed consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Surgery conversion rates	3 years	Negative conversion rate is: patients initially considered operable and subsequently not considered suitable for surgery compared to the total number of patients enrolled.; Positive conversion rate is: patients initially deemed ineligible for surgery and subsequently operated, compared to the total number of patients enrolled.

Secondary Outcome Measures

Name	Time	Method
Overall survival	3 years	Time from enrollment to death

Trial Locations

Locations (1)

Policlinico Agostino Gemelli; 🇮🇹 Roma, Italy