Pressure distribution in the thorax during mechanical ventilation and its effects on the circulatio
Recruiting
- Conditions
- Post-hartchirurgie patientenfluid challengevolume responsiveness
- Registration Number
- NL-OMON33072
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 22
Inclusion Criteria
Elective open heart surgery
Exclusion Criteria
Significant cardiac arrhythmias, including atrial fibrillation
Hemodynamically instability, as defined by a variation in heart rate, blood pressure and cardiac output of more than 10% during the 15-min period before starting the protocol.
Recent myocardial infarction (<3 mnd, troponine > 50ug/l)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study endpoint is a new dynamic parameter that is indexed to tidal<br /><br>volume to predict volume responsiveness and decrease the number of unnecessary<br /><br>(and potential harmful) fluid challenges on the ICU. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The second study endpoint is a physiological relational model that describes<br /><br>the distribution of breathing pressures during controlled and supported<br /><br>mechanical ventilation at 2 different thorax compliances. The third endpoint is<br /><br>a reliable method for the prediction of volume responsiveness with the<br /><br>combination of the Nexfin (noninvasive CO technique) and the passive leg<br /><br>raising test.</p><br>