Functional and effective connectivity of motor areas in parkinsons patients in comparision to healthy subjects belonging to two different groups of age.

• Conditions: G20; Parkinson disease

• Registration Number: DRKS00005635
• Lead Sponsor: AG für Bewegungsstörungen und Tiefe HirnstimulationKlinik und Poliklinik für Neurologie und Psychiatrie Uniklinikum Köln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-03-11
• Study Completion: 2014-07-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

Healthy subjects:

• male and female paticipants, age 20 to 40 mother language: german
• male and female paticipants, age 50 to 70, mother language: german
• capability of signing an informed consent

Parkinson's patients:
• male and female patients with the clinical diagnosis of an idopathic parkinson syndrom
• age between 40 and 80, motherlangue: german
• capability of signing an informed consent

Exclusion Criteria

Healthy participants:
• diagnosis of an idiopathic parkinson syndrom or any other neurological disease
• participants with a contraindication for an MR-scan like metal parts inside the body, i.e. cardiac pacemaker, stents etc.
• participants that take drugs regularly which influence the nervous system and which can not be stopped the evening befor the experiment
• pragnent or breast feeding mothers

Parkinson's patients:
• non- sui juris patients, underaged persons as well as subjects which are judically sent to an institution
• patients that suffer from another neurological disease apart from Parkinsons like Epilepsy, Alzheimers or Dystonia
• patients with claustrophobia
• participants with a contraindication for an MR-scan like metal parts inside the body, i.e. cardiac pacemaker, stents etc.
• patients with irregular MR-scans like ischemia, cerebral atrophy etc.
• former surgeries on the head especially for the implantation of electrodes for Deep Brain Stimulation Therapy
• pronounced head tremor that does not allow laying still in the MR and produces artefacts during EEG recordings
• presense of psychiatric diseases
• impaired vision or hearing defect that may hinder the testing
• pregnant or breast feeding mothers

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pathological coupling of motor areas depending on the complexity of a Tapping-task in Parkinson's patients.

Secondary Outcome Measures

Name	Time	Method
Prediction of behavioral errors during the performance of a Tapping-task in Parkinson's patients.