Nailfold Capillaroscopic Assessment in Pediatric Uveitis Patients

Completed

• Conditions: Uveitis

• Registration Number: NCT06070935
• Lead Sponsor: Assiut University

Brief Summary

Pediatric uveitis accounts for 5-10% of uveitis cases. it may be infectious or noninfectious in etiology. The etiology of noninfectious uveitis may be autoimmune. The most common causes of pediatric uveitis are idiopathic and juvenile idiopathic arthritis-associated uveitis. Uveitis morbidities in pediatric patients include cataract, glaucoma, and amblyopia. Pediatric uveitis may be accopanied by involvement of the ocular vasculature, such as retinal vasculitis. We hypothesize that there are differences in systemic microcirculation between pediatric uveitis patients and healthy pediatric controls.

Detailed Description

The systemic microcirculation will be investigated through nailfold capillaroscopic (NFC) assessment with noninfectious uveitis and healthy pediatric controls.

The NFC parameters are:

capillary density (number of capillaries per mm), dilated capillaries (apex of \>20µm), avascular areas, the presence of microhemorrhages, and capillary morphology (normal, multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries).

Study Timeline

• Study First Submitted: 2023-10-01
• Study First Submitted QC: 2023-10-01
• Study First Posted: 2023-10-06
• Study Start: 2024-01-01
• Primary Completion: 2024-05-30
• Study Completion: 2024-06-30
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-14
• Last Update Posted: 2024-08-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

• patients with uveitis < 18 years old

Exclusion Criteria

• infectious uveitis
• age > 18 years old

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
detection of number of dilated capillaries by nailfold capillaroscopy	6 months	number of dilated capillaries (apex of \>20µm)
detection of other abnormalities as avascular areas, microhemorrhages, and abnormal capillary morphology	6 months	detection of multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries
capillary density by nailfold capillaroscopy	6 months	(number of capillaries per mm)

Secondary Outcome Measures

Name	Time	Method
correlation of nailfold findings with uveitis activity	6 months	correlation of capillary abnormalities detected with active uveitis.

Trial Locations

Locations (1)

Maha Abdelrahman; 🇪🇬 Assiut, Egypt