Relationship Between Dopaminergic Asymmetric Degeneration and Attentional Resources in Parkinson's Disease.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 主要终点
- Auditory Reaction Times (A RTs)
研究概览
简要总结
The researchers aimed to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with Parkinson's disease (PD).
详细描述
To bypass the impaired habitual motor-behavioural control, Parkinson's disease (PD) patients may exploit the network of goal-directed mode of action. The frontostriatal connections underline this functioning, that is based on attention. Since the cognitive processes are related with dopamine, the asymmetrical degeneration of the dopaminergic system affects differently the right side affected (RPD) and the left side affected (LPD) PD patients.
The aim of the study was to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with PD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stage 2.5-3 according to the Hoehn and Yahr scale (H&Y);
- •Stable pharmacological treatment for the last 6 weeks before the enrolment and during the hospitalization;
- •Mini Mental State Examination (MMSE) ≥ 24;
- •No evidences of dysexecutive syndrome.
排除标准
- •Any focal brain lesion detected in brain imaging studies (CT or MRI) performed in the previous 12 months;
- •Drug-induced dyskinesias;
- •Disturbing resting and/or action tremor, corresponding to scores 2-4 in the specific items of UPDRS III;
- •Behavioral disturbances (evaluated with Neuropsychiatric Inventory);
- •Visual and auditory dysfunctions according to the general clinical evaluation and medical history;
- •Equivocal report about the side of disease onset or bilateral motor involvement.
研究组 & 干预措施
RPD PD patients
Right-side affected PD patients. Intervention: MIRT
干预措施: MIRT (Other)
LPD PD patients
Left-side affected (LPD) PD patients. Intervention: MIRT
干预措施: MIRT (Other)
结局指标
主要结局
Auditory Reaction Times (A RTs)
时间窗: 4 weeks
Auditory Reaction Times
Visual Reaction Times (V RTs)
时间窗: 4 weeks
Visual Reaction Times
Multiple Choices RTs (MC RTs)
时间窗: 4 weeks
Multiple Choices RTs
次要结局
- Unified Parkinson's Disease Rating Scale (UPDRS)(4 weeks)
- Timed Up and Go Test (TUG)(4 weeks)