Factors Associated With Successful Liberation From Continuous Renal Replacement Therapy In Critically Ill Patients: A Prospective Observational Study.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- To assesss the association between fluid balance gap % and liberation from CRRT
研究概览
简要总结
The study will be started after obtaining approval from Institute Ethics Committee
(IEC). Written and informed consent will be obtained. Patients planned for CRRT
will be enrolled after fulfilling inclusion criteria and their demographic data,
comorbidities, diagnosis, Acute Physiology and Chronic Health Evaluation
(APACHE II) score on critical care unit admission, Sequential Organ Failure
Assessment (SOFA) score on admission will be noted. Also their on admission
vitals, ABG and renal parameters (urea, creatinine, creatinine clearance, and urine
output) will be recorded.
The SOFA score, vitals, ABG parameters, Renal parameters and cumulative fluid
balance will be noted on CRRT initiation and liberation. Also VIS maximum in
the last 24 hours before initiating CRRT and at the time of CRRT liberation will
be recorded
On CRRT daily FB goal, FB achieved and FB gap % will be recorded till the time
patient is on CRRT. Time duration from AKI to CRRT initiation and total duration
of CRRT will also be recorded.
The patient will be liberated from CRRT based on clinical judgment and if
following criteria met
Creatinine clearance > 15 ml/minute
Spontaneous urine output > 500 ml/day
Hemodynamic stability
The whole data will be compared among patients successfully liberated from
CRRT and CRRT reinstituted group for any statistical significance.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •Acute Kidney Injury Acute on Chronic Kidney Disease Hemodynamic Instability.
排除标准
- •CONCURRENT ECMO CRRT FOR DIFFERENT PRIMARY INDICATION(EG.
- •ACUTE LIVER FAILURE, INTOXICATION) H/O RENAL TRANSPLANT MORTALITY WITHIN 24 HOUR OF CRRT.
结局指标
主要结局
To assesss the association between fluid balance gap % and liberation from CRRT
时间窗: every day from the start of CRRT till the patient is on CRRT
次要结局
- To assess the association between Vasoactive ionotropic score & liberation from CRRT(every day from the start of CRRT till the patient is on CRRT)
- To study the association between disease severity measured by SOFA & APACHE-2 on admission,CRRT initiation & liberation from CRRT(every day from the start of CRRT till the patient is on CRRT)
研究者
Satish Patel
AIIMS Raipur