跳至主要内容
临床试验/CTRI/2022/11/047778
CTRI/2022/11/047778尚未招募不适用

Comparison of left atrial strain and p wave dispersion as a predictor of postoperative atrial fibrillation in patients undergoing coronary artery bypass graft

All India Institute Of Medical Sciences1 个研究点 分布在 1 个国家目标入组 72 人开始时间: 2022年8月12日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
72
试验地点
1
主要终点
1. To compare Left Atrial Strain With P-Wave Dispersion as a predictor of postoperative atrial

研究概览

简要总结

Postoperative atrial fibrillation (POAF) complicates 15% to 40% of cardiovascular surgeries. This arrhythmia though transient can increase the risk of embolic stroke, prolonged hospital stay and cardiovascular mortality.  Alterations in oxidative stress, calcium handling, mitochondrial dysfunction, inflammation, fibrosis, and tissue aging are among the mechanisms that predispose patients to the “atrial stormâ€. Manifestations of these mechanisms have been related to enlarged atria and impaired function, which can be detected prior to surgery. Alterations in the atrial reservoir and pump function, as well as atrial dyssynchrony determined by echocardiographic atrial strain, can predict POAF and help to shed light on which patients could benefit from preventive therapy. Currently, there is no one reliable way to determine preoperatively which patients will develop POAF following CABG. The aim of this study is to determine whether preoperative left atrial strain assessment and P wave dispersion can identify patients who likely to develop POAF following CABG.

研究设计

研究类型
Observational

入排标准

年龄范围
40.00 Year(s) 至 80.00 Year(s)(—)
性别
All

入选标准

  • All Elective Coronary Artery Bypass Graft Surgery.

排除标准

  • Patients with acute coronary syndromes
  • Patients with preoperative complication of myocardial infarction (ventricular septal rupture/ LV aneurysm)
  • Patients with significant preoperative valvular heart disease
  • Patients with preoperative cardiomyopathies
  • Patients on preoperative mechanical ventilation or dialysis
  • Previous history of cardiac surgery
  • Emergency surgery.

结局指标

主要结局

1. To compare Left Atrial Strain With P-Wave Dispersion as a predictor of postoperative atrial

时间窗: At Base line,after surgery and postoperative period till 3 days

fibrillation in patients undergoing coronary artery bypass graft (CABG) .

时间窗: At Base line,after surgery and postoperative period till 3 days

2. To find out sensitivity, specificity, threshold (cutoff point) of Left atrial strain parameters and P

时间窗: At Base line,after surgery and postoperative period till 3 days

wave dispersion to predict POAF in CABG

时间窗: At Base line,after surgery and postoperative period till 3 days

次要结局

  • To observe hemodynamic changes,duration of intubation,length of hospital stay(At base line, After revascularization and till 3 days)

研究者

申办方类型
Research institution and hospital

研究点 (1)

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