Evaluation of ketamine in managing post operative pain following laproscopic cholecystectomy

Completed

Conditions: ASA I and II patients undergoing laproscopic cholecystectomy
Calculus of gallbladder without cholecystitis,

Brief Summary: Patients undergoing laparoscopic cholecystectomy (LC) experience lesser post-operative pain than conventional cholecystectomy. 1 However, pain remains the dominant complaint of patients on the first post operative day.2,3 Effective post operative analgesia after LC has always remained a clinical challenge. This acute pain also predisposes the development of chronic pain at port sites in LC patients.

NMDA is a receptor for the excitatory neurotransmitter glutamate, which is released with noxious peripheral stimuli. The activation of NMDA receptors has been associated with hyperalgesia, neuropathic pain and chronic pain. Thus leading to the possibility that NMDA receptor antagonist may be useful in treatment of chronic pain. Ketamine, a NMDA antagonist may be used as an analgesic which can be used for acute as well as chronic pain in LC patients.

Recruitment & Eligibility

Inclusion Criteria

ASA grade I and II patients of either sex, between 20-60 yrs of age, undergoing elective laparoscopic cholecystectomy under general anesthesia,.

Exclusion Criteria

The patients unable to understand NRS, allergic to local anesthetics, had chronic pain disease other than gall stone disease, choledocholithiasis, acute pancreatitis, or were pregnant, were excluded from the study.
Whenever surgical procedure necessitated the conversion of laproscopic cholysectomy to open procedure, such patients was also excluded from the study.

Primary Outcome Measures

Name	Time	Method
The length of time between extubation and the first request for pain medication was recorded.	The length of time between extubation and the first request for pain medication was recorded. \| Chronic pain will be asked from the patient every 15 days on telephone till 6 months post surgery.
Chronic pain (NRS score)will be asked from the patient every 15 days on telephone till 6 months.	The length of time between extubation and the first request for pain medication was recorded. \| Chronic pain will be asked from the patient every 15 days on telephone till 6 months post surgery.

Secondary Outcome Measures

Name	Time	Method
The total and cumulative consumption of analgesics (tramadol) will be recorded after 24 hours.	24 hours
shoulder pain, nausea, vomiting were also recorded.	24 hours

Locations (1): School of Medical sciences and Research
🇮🇳
Nagar, UTTAR PRADESH, India
School of Medical sciences and Research
🇮🇳Nagar, UTTAR PRADESH, India
Dr Shruti Jain
Principal investigator
9212308441
shruti.anaesth@gmail.com