The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect
Phase 3
Recruiting
- Conditions
- Chronic Kidney Diseases
- Registration Number
- NCT06058585
- Lead Sponsor
- The George Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 1000
Inclusion Criteria
Inclusion Criteria:<br><br> 1. Age = 18 years<br><br> 2. Known chronic kidney disease from any cause (eGFR =25 mL/min/1.73m2)<br><br> 3. Currently receiving standard of care treatment according to treating physician<br><br> 4. Eligible for randomisation in at least one recruiting domain-specific appendix<br><br> 5. Participant and treating physician are willing and able to perform trial procedures<br><br>Exclusion Criteria:<br><br> 1. Planned to commence kidney replacement therapy or kidney transplant surgery in next<br> 6 months<br><br> 2. Life expectancy less than 6 months
Exclusion Criteria
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eGFR slope
- Secondary Outcome Measures
Name Time Method Change in albuminuria;Composite of 40% eGFR decline or kidney failure;All-cause mortality at 108 weeks;Number of cardiovascular events;Safety and tolerability of treatment;Change in quality of life