Zoledronic Acid in Decrease the Lung Metastatic Rate of Osteosarcoma
- Registration Number
- NCT03932071
- Lead Sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- Brief Summary
Zoledronic acid is an adjuvant treatment for primary osteosarcoma. Zoledronic acid has been widely used in the treatment of metastatic bone tumors. In addition to its inhibition of tumor osteoclasis, it also produces certain killing of tumor cells. effect. Foreign studies have shown that zoledronic acid also has a killing effect on osteosarcoma and has a certain inhibitory effect on distant metastasis. We hope that it can reduce tumor recurrence and lung metastasis through this study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 150
- Patients with osteosarcoma who were diagnosed with initial pathology and pathology were excluded from lung metastasis or other metastatic lesions by CT and total body emission-computed tomography, and patients with standard chemotherapy were evaluated.
- Pulmonary metastasis, pregnancy or lactation, renal insufficiency (creatinine clearance <70 ml/min/1.73 m2), liver dysfunction, obvious oral disease, and unsuitable for bisphosphonate treatment after evaluation, have been found. With diseases that still require hormone therapy, abnormal blood system, heart disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description experimental group Zoledronic Acid -
- Primary Outcome Measures
Name Time Method rate of lung metastasis 3 year Discovery the rate of neonatal lung metastases by high-resolution chest CT
rate of tumor recurrence 3 year Local recurrence rate of tumor or rate of distant metastasis
- Secondary Outcome Measures
Name Time Method rate of tumor necrosis less than 90% 3 year the rate of patients that postoperative tumor necrosis rate was estimated to be lower than grade III（90%）
Trial Locations
- Locations (1)
2nd Affiliated Hospital of Zhejiang University
🇨🇳Hangzhou, Zhejiang, China