The Effect of Vitamin K Supplementation on Glucose Metabolism
- Registration Number
- NCT00960973
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response.
- Detailed Description
Recently, many studies have reported that vitamin K metabolism is related to glucose metabolism. The suggested mechanisms connecting vitamin K metabolism and glucose metabolism, are inflammation responses and osteocalcin effect on glucose metabolism. Most of the studies have investigated fasting glucose and insulin sensitive index, few have assessed glucose-intake-stimulated responses in regard to vitamin K supplementation. The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response using intravenous glucose tolerance test.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 42
- Healthy male volunteer older than 20 years
- Subjects with (a history of) diabetes
- Subjects receiving medication related to diabetes or obesity
- Subjects receiving warfarin
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo control Placebo Placebo control Vitamin K Menatetrenone Vitamin K supplementation (menatetrenone 30 mg, 3 times a day for 4 weeks)
- Primary Outcome Measures
Name Time Method AIRg (acute insulin response to glucose) using FSIGT (frequently sampled intravenous glucose tolerance test) 4 weeks later
- Secondary Outcome Measures
Name Time Method beta-cell function (FSIGT) 4 weeks later disposition index (FSIGT) 4 weeks later insulin sensitivity (FSIGT) 4 weeks later
Trial Locations
- Locations (1)
Seoul National University Medical School
🇰🇷Seoul, Korea, Republic of