Vitamin D Serum Levels in Monosymptomatic Enuretic and Non Enuretic Children

Completed

• Conditions: Nocturnal Enuresis
• Interventions: Diagnostic Test: serum vitamin D; Diagnostic Test: urine osmolality; Other: Frequency volume chart

• Registration Number: NCT06243042
• Lead Sponsor: Ain Shams University

Brief Summary

We are group of researchers interested in causes and management of nocturnal enuresis, we embarked on this research on 2020 and we reached promising results regarding the role of vitamin D serum level in etiology and management of monosymptomatic enuresis.

Detailed Description

this research was conducted as a comparative study regarding serum vitamin D levels in monosymptomatic enuretic and non enuretic children, also we compared urine osmolality and nocturnal polyuria in both groups and we found that low vitamin D levels are correlated with low nocturnal urine osmolality and increased incidence of nocturnal polyuria

Study Timeline

• Study Start: 2020-02-12
• Primary Completion: 2020-08-30
• Study Completion: 2020-09-24
• Status Verified: 2024-01
• Study First Submitted: 2024-01-04
• Study First Submitted QC: 2024-01-28
• Last Update Submitted: 2024-01-28
• Study First Posted: 2024-02-06
• Last Update Posted: 2024-02-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients with PMNE.
• which was defined as bedwetting frequency of 3 or more nights per week for at least 2 weeks of observation.
• Didn't receive any previous treatment for enuresis.

Exclusion Criteria

• Patients with non-monosymptomatic enuresis (associated with storage and/or voiding symptoms). -Patients with anatomical abnormalities (Meatal stenosis, Hypospadias, Epispadias, etc.).
• Patients with neurological diseases.
• Patients with Renal impairment.
• Patient with previous pelvic, urological or brain and spinal cord surgery.
• Patients with chronic constipation and irritable bowel habits.
• Patients with active urinary tract infection.
• Patients who are on vitamin D supplements.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Enuretic	urine osmolality	Children complaining of monosymptomatic enuresis
Enuretic	Frequency volume chart	Children complaining of monosymptomatic enuresis
Non-enuretic	serum vitamin D	Healthy non enuretic children
Enuretic	serum vitamin D	Children complaining of monosymptomatic enuresis
Non-enuretic	Frequency volume chart	Healthy non enuretic children
Non-enuretic	urine osmolality	Healthy non enuretic children

Primary Outcome Measures

Name	Time	Method
Vitamin D level	through study completion, average 1 year.	low vitamin d levels in enuretic group

Secondary Outcome Measures

Name	Time	Method
nocturnal polyuria	through study completion, average 1 year.	frequency volume chart idobtained
low nocturnal urine osmolality	through study completion, average 1 year.	nocturnal urine osmolality

Trial Locations

Locations (1)

Cairo; 🇪🇬 Cairo, Egypt