Evaluation of efficacy of Platelet rich fibrin in healing of surgical removal of oral mucosal lesions
Not Applicable
- Conditions
- Health Condition 1: K132- Leukoplakia and other disturbancesof oral epithelium, including tongue
- Registration Number
- CTRI/2023/09/057224
- Lead Sponsor
- ady Hardinge Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients with oral mucosal lesions of size less than 5 cm in its greatest dimension.
2. Age group- 18-60 years
Exclusion Criteria
1.With systemic diseases like diabetes mellitus, hypertension, thyroid disorders, immunocompromised state, etc.
2.H/O chemotherapy or radiotherapy
3.On long-term antibiotic, steroid or antiplatelets
4.Active local and/or systemic infection
5.Pregnant and lactating women and those taking oral contraceptives.
6.Hemoglobin level less than 10 gm/dL
7.Platelet count less than 100 ×103/µL
8.H/O allergy to local anesthetic agents like Xylocaine.
9.Chronic Alcoholic- >4 drinks/day or 14-15 drinks in a week.
10. Smoker- 100 cigarettes in his/her lifetime or currently smokes cigarettes.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Comparison of IPR healing scores between group 1, group 2 & group 3Timepoint: post-operative 4th day, 14th day, 6 weeks between the three groups.
- Secondary Outcome Measures
Name Time Method 1.Comparison of scores of VAS for severity of pain assessment <br/ ><br>2.To record & compare the presence the granulation tissue formed <br/ ><br>3.To record and compare the epithelization of wound <br/ ><br>4.To record and compare the wound contracture <br/ ><br>5.To record and compare any complicationsTimepoint: post-operative 4th day, 14th day, 6 weeks between the three groups