Comparing the Efficacy of14 days Reverse Hybrid Regimen and 14 days concomitant Therapy for HP eradicatio
Not Applicable
- Conditions
- Gastric Ucer.gastric ulcer
- Registration Number
- IRCT2017081215510N3
- Lead Sponsor
- Technology Assistant, Mazandaran University Of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 260
Inclusion Criteria
Patients with endoscopic findings of gastric or duodenal ulcer or gastric and duodenal erosoin and have Helicobacter pylori infection ; patients older than 18 year and less than 80 years. Exclusion criteria : pregnancy and lactation ; previously received Helicobacter pylori therapy ; patients received PPI (poroton poup inhibitor) or H2 RA (histamine 2 receptor antagonist) in last 2 weeks or within 4 weeks who received antibiotics ; history of surgery on the stomach ; Patients with confirmed advanced disease , severe cardiac, pulmonary , endocrine , chronic renal failure, chronic liver disease or have cancer ; The consumption of alcoholic beverages
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Helicobacter pylori infection. Timepoint: Before intervention and 12 weeks after intervention. Method of measurement: Upper GI endoscopy and biopsy for pathology and RUT for HP infection before intervention and endoscopy and biopsy or urea breath test and or stool examination for HP antigen for HP infection after intervention.
- Secondary Outcome Measures
Name Time Method HP eradication rate and drug adverse effects and patients compliance in two groups. Timepoint: 12 weeks after initiation of therapautic regimens. Method of measurement: Urea breath test, stool exam for HP antigen and or endoscopy and biopsy. questionary assesment.