Changes in Food Preference and Food Cue Responsivity After Bariatric Surgery

• Conditions: Roux-en-Y Gastric Bypass
• Interventions: Procedure: Roux-en-Y Gastric Bypass

• Registration Number: NCT02068001
• Lead Sponsor: Wageningen University

Brief Summary

It has been suggested that obese people are more sensitive to sensory and rewarding effects of food, aspects that mediate food preferences and intake. Individuals that underwent Roux-en-Y gastric bypass surgery frequently report changes in food preference. They indicate a decreased preference for highly rewarding energy dense foods. Changes in food preference might be related to alterations in central (brain) mechanisms, related to reward sensing. The smell and sight of food can be considered as anticipatory cues for the rewarding effects of food intake. The aim of this study is to determine the effect of gastric bypass surgery on (alterations in) food preferences. Secondly, this study aims at assessing the effect of gastric bypass surgery on the brain reward response when exposed to sight and smell of food stimuli with different sugar and fat contents.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-02-05
• Study First Submitted QC: 2014-02-17
• Study First Posted: 2014-02-20
• Study Start: 2014-07
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-22
• Last Update Posted: 2017-05-23
• Primary Completion: 2017-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Scheduled for Roux-en-Y Gastric Bypass Surgery at Rijnstate hospital

Exclusion Criteria

• Lack of appetite
• Having difficulties swallowing/eating
• Being a vegetarian
• Allergic to food product used as stimuli in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
RYGB	Roux-en-Y Gastric Bypass	Food preference assessment in 100 patients at different timepoints, in a subset of 30 participants, also brain reward response to food cues will be assessed.

Primary Outcome Measures

Name	Time	Method
Change in brain reward response to food cues	Before and 2 months after surgery	Two weeks before and two months after Roux-en-Y Gastric Bypass the brain reward response to the sight and smell of food will be assessed in a subset of 30 participants.
Development of food preferences after Roux-en-Y gastric bypass surgery	Participants will be followed for two years after they undergo surgery	Food preferences will be assessed 2 weeks before Roux-en-Y Gastric Bypass surgery and 2 months, 1 year and 2 years after surgery.

Secondary Outcome Measures

Name	Time	Method
Plasma levels of endocannabinoids and satiety hormones	Before and 2 months after surgery	Two weeks before and two months after Roux-en-Y gastric bypass surgery, fasted plasma levels of endocannabinoids, ghrelin, leptin, adiponectin and Glucagon-Like Peptide will be assessed in a subset of 30 participants.

Trial Locations

Locations (3)

Rijnstate Hospital; 🇳🇱 Arnhem, Gelderland, Netherlands

Gelderse Vallei Hospital; 🇳🇱 Ede, Gelderland, Netherlands

Wageningen University; 🇳🇱 Wageningen, Gelderland, Netherlands