12-Week Study on the Efficacy of Two Serums in Improving Skin Aging and Tone

Not Applicable

Completed

• Conditions: Facial Skin Aging and Dullness

• Registration Number: NCT07156071
• Lead Sponsor: ChinaNorm

Brief Summary

This study aims to evaluate the anti-aging and skin tone improvement effects of two facial serums over a 12-week period. It was conducted at a single research center with a 2-week washout period followed by full-face application of the test products for 12 weeks.

A total of at least 120 healthy Chinese female participants aged 18 to 45 were enrolled and divided into two treatment groups:Each group included both early aging (18-29 years) and mature aging (30-45 years) subgroups, with at least 30 participants in each subgroup.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-11-18
• Primary Completion: 2024-03-01
• Study Completion: 2024-03-22
• Study First Submitted: 2025-08-20
• Status Verified: 2025-09
• Study First Submitted QC: 2025-09-03
• Last Update Submitted: 2025-09-03
• Study First Posted: 2025-09-04
• Last Update Posted: 2025-09-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 120

Inclusion Criteria

1. Chinese female aged 18-45 years (evenly split among Early aging [18-29 years] and Mature aging [30-45 years]).

2. All skin types (dry, normal, oily, or mixed).

3. Currently experiencing lack of radiance, roughness, dullness, and fine lines or wrinkles on facial skin as self-claimed.

4. Early aging group (18-29 years): Must present with corresponding severity for the attributes evaluated by Dermatologist, including:

   • Skin smoothness, radiance, dullness: grade between 2 and 6 (scale 0-9);
   • Size of acne marks (PIH): size ≥ 2;
   • Small folds on nasolabial zone: grade between 1 and 3 (Skin Aging Atlas, 0-6 scale, Page 56-57).

5. Mature aging group (30-45 years): Must present with corresponding severity for the attributes evaluated by Dermatologist, including:

   • Skin smoothness, radiance, dullness: grade between 4 and 6 (scale 0-9);
   • Small folds on nasolabial zone: grade between 1 and 4 (Skin Aging Atlas, 0-6 scale, Page 56-57);
   • Forehead wrinkles: grade ≥ 2 (Skin Aging Atlas, 0-8 scale, Page 32-33);
   • Crow's feet wrinkles: grade ≥ 2 (Skin Aging Atlas, 0-6 scale, Page 40-41).

6. Regular user of serum and sunscreen products.

7. Did not participate in any clinical test or cosmetic product test on skin within the last 3 months.

8. No exclusion by dermatologist due to other medical or dermatological reasons.

9. In general good health at the time of the study.

10. Willing and able to participate as evidenced by signing of informed consent and photo release form.

11. Must be willing to comply with all study protocol requirements (including using only the skincare products provided during the study and not taking topical or oral treatments such as retinol, hormones, or antioxidant health supplements).

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in Dermatologist-Assessed Wrinkle Attributes	from Baseline to Week 12	Crow's feet wrinkles, forehead wrinkles, global wrinkles, small folds on nasolabial zone and global fine lines will be evaluated by dermatologist.
Self-assessment Questionnaire	12 weeks	Participants will complete a 5-point self-assessment questionnaire at Timm, T4w, T8w, and T12w, evaluating their perception of skin softness, smoothness, plumpness, elasticity, hydration, oil control, and visible aging signs. Ratings from 4 to 5 will be used to calculate "Top 2 box" percentage.
Change in Dermatologist-Assessed Skin Texture and Quality Attributes	from Baseline to Week 12	Skin smoothness (visual), skin elasticity, skin softness, skin firmness, skin plumpness, cheek pores will be evaluated by dermatologist.
Change in Dermatologist-Assessed Skin Tone Attributes	from Baseline to Week 12	Skin radiance, skin translucency, skin pigmentation, skin fairness, skin tone evenness and skin dullness will be evaluated by dermatologist.

Secondary Outcome Measures

Name	Time	Method
Change in Skin Hydration Measured by Corneometer	12 weeks
Change in Skin Elasticity Measured by Cutometer	12 weeks
Change in Transepidermal Water Loss (TEWL) Measured by Vapometer	12 weeks
Change in Facial Image-Based Skin Parameters Using VISIA-CR	12 weeks
Change in Cheek Skin Surface Condition Using VisioScan VC20	12 weeks

Trial Locations

Locations (1)

Shanghai China-norm Quality Technical Service Co., Ltd., Shanghai, Shanghai 200072; 🇨🇳 Shanghai, China