The Prognostic Value of Blood Biomarkers for Patients With Polyneuropathy.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Disease Severity
研究概览
简要总结
Biomarkers for prognosis of patients with polyneuropathy.
详细描述
AIM: To investigate biomarkers' use as a prognostic tool in polyneuropathy patients.
STUDY DESIGN: Prospective cohort study of patients with polyneuropathy. METHODS: 200 patients with polyneuropathy will be examined with physical tests, medical examination, questionnaires, and blood biomarkers at baseline and at 1-year follow-up, and 2-year follow-up.
ANALYSIS: The investigators will calculate the odds of disease progression after 2 years depending on biomarkers levels at baseline using multiple logistic regression with sex and age adjustment. Diagnostic performance of the physical tests and biomarkers for prediction of disease progression will be assessed by Receiver Operating Characteristic Curve analysis with the area under the curve.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Minimum 18 years old.
- •Diagnosed with polyneuropathy, confirmed by nerve conduction study.
- •Can read and understand Danish.
排除标准
- •Inability to perform physical tests due to comorbidity not associated to the patient's polyneuropathy.
结局指标
主要结局
Disease Severity
时间窗: 2 years
Primary outcome is disease severity
次要结局
- Patient Reported Outcomes (PROMs)(2 years)
研究者
Louise Sloth Kodal
MD
Rigshospitalet, Denmark