NCT03357887已完成不适用
Prognostic Value of Three New Biomarkers of Multiple Sclerosis Compared to Reference Biomarker in Patients With Radiologically Isolated Syndrome
Centre Hospitalier Universitaire de Nīmes1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2018年7月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Level of Neurofilament in cerebrospinal fluid
研究概览
简要总结
To look at the prognostic value of new biomarkers in CSF and serum for characterisation of multiple sclerosis
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Level of Neurofilament in cerebrospinal fluid
时间窗: Baseline
ELISA
Level of GFAP in cerebrospinal fluid
时间窗: Baseline
ELISA
Level of tumour necrosis factor receptor in cerebrospinal fluid
时间窗: Baseline
ELISA
Level of secreted glycoprotein in cerebrospinal fluid
时间窗: Baseline
ELISA
次要结局
- Level of GFAP in serum(Baseline)
- Level of Neurofilament in serum(Baseline)
- Level of secreted glycoprotein in serum(Baseline)
- Compare prognostic value of all four markers of the high risk criteria (age below 37, male, myelitis).(Baseline)
- Biomarker levels in CSF and serum in different patient subpopulations (Radiologically Isolated Syndrome, recurrent remittent MS, symptomatic controls, central nervous system inflammatory disease controls, non-inflammatory disease controls)(Baseline)
- Level of tumour necrosis factor receptor in serum(Baseline)
- Comparison of the conversion time according to the threshold value of each biomarker for Radiologically Isolated Syndrome patients(Baseline)
研究者
研究点 (1)
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