Impact of HMGB1 on Diastolic Dysfunction in Hypertensive Patients

• Conditions: Diastolic Dysfunction; Hypertension; Inflammation

• Registration Number: NCT03177408
• Lead Sponsor: Jing Li

Brief Summary

This study evaluated the association between HMGB1 and diastolic dysfunction in hypertensive patients. HMGB1 level were tested in all patients, and diastolic function determined by echocardiographic.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-04-16
• Status Verified: 2017-06
• Study First Submitted QC: 2017-06-04
• Last Update Submitted: 2017-06-04
• Study First Posted: 2017-06-06
• Last Update Posted: 2017-06-06
• Study Start: 2017-08-15
• Primary Completion: 2017-12-31
• Study Completion: 2017-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

All of the hypertensive patients in both diastolic dysfunction and control groups were either newly diagnosed or were aware of hypertension without using any pharmacotherapy.

Exclusion Criteria

Individuals already under treatment for hypertension were not include.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences of HMGB1 levels between hypertensive patients with and without diastolic dysfunction	on the day of admission	Blood samples of all individuals are collected on the day of admission and HMGB1 levels are tested. Echocardiographic assessment is performed with echocardiography device by using 2.5-3.5 Mega Hertz(MHz) transducer in the lateral decubitis position.

Secondary Outcome Measures

Name	Time	Method
Differences of HMGB1 levels between grades of diastolic dysfunction	on the day of admission	Blood samples of all individuals are collected on the day of admission and HMGB1 levels are tested. Echocardiographic assessment is performed with echocardiography device by using 2.5-3.5 Mega Hertz(MHz) transducer in the lateral decubitis position.