Early removal of Fallopian tubes and delayed removal of ovaries in women at high risk of ovarian cancer

Not Applicable

• Conditions: Prevention of ovarian cancer; Cancer; Ovarian cancer

• Registration Number: ISRCTN25173360
• Lead Sponsor: Queen Mary University of London

Brief Summary

2020 protocol in https://pubmed.ncbi.nlm.nih.gov/32907814/ (added 11/09/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-06-14
• Last Update Posted: 22 March 2021
• Study Completion: 2028-07-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: Female
• Target Recruitment: 1000

Inclusion Criteria

1. Women at increased risk of ovarian cancer: BRCA1/BRCA2 mutation carriers; RAD51C/RAD51D/BRIP1 mutation carriers; strong family history of breast and ovarian cancer or ovarian cancer alone.
2. Premenopausal
3. Aged =30 years.
4. Completed family (for surgical arms)

Exclusion Criteria

1. Previous bilateral-salpingectomy or bilateral-oophorectomy.
2. Postmenopausal (amenorrhoea =1year (uterus in situ) / FSH >40).
3. Previous tubal/ovarian/peritoneal malignancy
4. <12 months post cancer treatment
5. Pregnancy
6. Clinical suspicion of tubal/ovarian cancer at baseline
7. Inability to provide informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sexual function measured using the Sexual Activity Questionnaire and Sexual Quality of Life 3D (SQOL-3D) questionnaire completed at baseline, 3 months post surgery and annually.