Influence of menarche and menstrual cycle on QTc interval in girls with genotype positive LQT1 and LQT2

Completed

• Conditions: Congenital long QT syndrome; LQTS; 10083624

• Registration Number: NL-OMON45048
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 25

Inclusion Criteria

All girls must meet the following inclusion criteria
* Post-menarcheal
* Genetically confirmed LQT1 and LQT2
* Between the age of 12 and 21 years

Exclusion Criteria

* Premenarcheal
* Pregnancy
* The use of hormonal contraceptive therapy (i.e. combined estrogen-
progestin oral contraceptives, intrauterine contraception, contraceptive vaginal ring, etonogestrel contraceptive implant, injectable contraceptives or progestin pills)
* Body mass index (BMI) for age greater or less than the 95th percentile
* History of polycystic ovary syndrome (PCOS) or anorexia nervosa
* Double mutation carrier or compound heterozygote
* Mutations of unknown pathology

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The QTc interval will be measured pre- and post-menarche and during three<br /><br>phases of the menstrual cycle, with concomitant estradiol and pregnanediol<br /><br>fluctuations. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NA</p><br>