Influence of menarche and menstrual cycle on QTc interval in girls with genotype positive LQT1 and LQT2
- Conditions
- Congenital long QT syndromeLQTS10007510
- Registration Number
- NL-OMON40681
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 0
All girls and boys born between January 1st 1985 and December 31st 2001, who are diagnosed based on their genotype with LQT1 or LQT2 and seen in the Academic Medical Centre in Amsterdam between January 1st 2003 and December 31st 2013, will be included in the study population.
- Premenarcheal
- Pregnancy
- Use of hormonal contraceptive therapy other than combined estrogen-progestin oral contraceptives (i.e. intrauterine contraception, contraceptive vaginal ring, etonogestrel contraceptive implant, injectable contraceptives or progestin pills)
- Double mutation carriers or compound heterozygote
- Body mass index (BMI) for age greater than the 95th percentile
- History of polycystic ovary syndrome (PCOS)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The QTc interval will be measured pre- and post-menarche and during 3 phases of<br /><br>the menstrual cycle. In boys QTc interval will be measured at approximately<br /><br>the same time intervals as the girls during their menstrual cycle. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable</p><br>
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