Influence of the Menstrual Cycle on the QT interval in females with Long QT-syndrome
- Conditions
- long QT syndromeLQTS1000752110007510
- Registration Number
- NL-OMON54957
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Genetically confirmed LQT1 or LQT2
Age between 12 and 30 years
Exclusion Criteria
Pregnancy and post-partum period until the end of breastfeeding
The use of hormonal contraceptive therapy other than combined
oestrogen-progestin oral contraceptives (i.e. intrauterine contraception,
contraceptive vaginal ring, etonogestrel contraceptive implant, injectable
contraceptives or progestin pills)
History of anorexia nervosa or polycystic ovary syndromeHistory of anorexia
nervosa or PCOS
BMI for age greater or less than the 99th percentile
Double mutation carrier or compound heterozygote
Mutations of unknown pathogenicity
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Concomitant estradiol and pregnanediol fluctuations will be obtained together<br /><br>with the QTc at three time points during the menstrual cycle or approximately<br /><br>corresponding with the phases of the menstrual cycle in LQTS-females with and<br /><br>without HCT, respectively. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Daily QTc fluctuations during 1 month in men and women both with and without<br /><br>HCT. </p><br>