The Effect of Dexmedetomidine on Propofol Requirement for Insertion of Laryngeal Mask Airway
- Conditions
- Precedex Effect to Propofol Requirement
- Interventions
- Drug: Normal saline
- Registration Number
- NCT02284672
- Lead Sponsor
- Ajou University School of Medicine
- Brief Summary
Propofol frequently used as an inducting medication for insertion Laryngeal mask airway(LMA). But propofol alone can be not sufficient for inhibiting upper airway reflex and also result in cardiovascular suppression under enough amount. Dexmedetomidine is a selective alplh2 receptor agonist with analgesic and sedative effects but sparing respiratory function. Therefore propofol combined with dexmedetomidine induction could be more effective in preserve respiration under same condition for LMA insertion than propofol alone. In this study, the investigators investigate the clinical dose of propofol for LMA insertion with premedication of dexmedetomidine, and evaluate the effect of dexmedetomidine.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 39
- patients for surgery not exceed more than 2 hours requiring general anesthesia
- history of gastroesophageal reflux High grade obesity Predicted diffiicult airway
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description control Normal saline After preoxygenation for 3 minutes, normal saline would be injected to patient for 10 minute. First, 1% lidocaine 3 ml were given for reducing injection pain of propofol and the settled amount of propofol was injected during 15 seconds. After 90 seconds, other anesthesiologist who did'nt know the injected drug tried to insert LMA. dexmedetomidine Dexmedetomidine After preoxygenation for 3 minutes, dexmedetomidine would be injected to patient for 10 minute. First, 1% lidocaine 3 ml were given for reducing injection pain of propofol and the settled amount of propofol was injected during 15 seconds. After 90 seconds, other anesthesiologist who did'nt know the injected drug tried to insert LMA.
- Primary Outcome Measures
Name Time Method Fail or success for Laryngeal Mask Airway (LMA) insertion During inserting LMA and up to 5 seconds after LMA inserion Failure for LMA insertion is defined if there is a difficulty for mouth opening or active movement of four limbs or head. Success is smooth LMA insertion without any movement
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Jiyoung Yoo
🇰🇷Suweon, Kyunggido, Korea, Republic of
Jiyoung Yoo🇰🇷Suweon, Kyunggido, Korea, Republic of