The Effect of Dexmedetomidine on Propofol Requirement for Insertion of Laryngeal Mask Airway
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Fail or success for Laryngeal Mask Airway (LMA) insertion
研究概览
简要总结
Propofol frequently used as an inducting medication for insertion Laryngeal mask airway(LMA). But propofol alone can be not sufficient for inhibiting upper airway reflex and also result in cardiovascular suppression under enough amount. Dexmedetomidine is a selective alplh2 receptor agonist with analgesic and sedative effects but sparing respiratory function. Therefore propofol combined with dexmedetomidine induction could be more effective in preserve respiration under same condition for LMA insertion than propofol alone. In this study, the investigators investigate the clinical dose of propofol for LMA insertion with premedication of dexmedetomidine, and evaluate the effect of dexmedetomidine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 19 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients for surgery not exceed more than 2 hours requiring general anesthesia
排除标准
- •history of gastroesophageal reflux High grade obesity Predicted diffiicult airway
研究组 & 干预措施
control
After preoxygenation for 3 minutes, normal saline would be injected to patient for 10 minute. First, 1% lidocaine 3 ml were given for reducing injection pain of propofol and the settled amount of propofol was injected during 15 seconds.
After 90 seconds, other anesthesiologist who did'nt know the injected drug tried to insert LMA.
干预措施: Normal saline (Drug)
dexmedetomidine
After preoxygenation for 3 minutes, dexmedetomidine would be injected to patient for 10 minute. First, 1% lidocaine 3 ml were given for reducing injection pain of propofol and the settled amount of propofol was injected during 15 seconds.
After 90 seconds, other anesthesiologist who did'nt know the injected drug tried to insert LMA.
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
Fail or success for Laryngeal Mask Airway (LMA) insertion
时间窗: During inserting LMA and up to 5 seconds after LMA inserion
Failure for LMA insertion is defined if there is a difficulty for mouth opening or active movement of four limbs or head. Success is smooth LMA insertion without any movement
次要结局
未报告次要终点
研究者
Jiyoung Yoo
clinical assistant professor
Ajou University School of Medicine